反应详情

温度

90 °C

A mixture of ethyl 4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxylate (50 mg, 0.125 mmol) from Step D in neat 1-aminopiperidine (1 mL) was heated at 90° C. for 72 hr. Most of the amine was evaporated under a stream of nitrogen and the residue was purified by Prep TLC (2×1 mm, silica) (40% ethyl acetate in hexanes to afford the title compound.

1. customMost of the amine was evaporated under a stream of nitrogen
2. customthe residue was purified by Prep TLC (2×1 mm, silica) (40% ethyl acetate in hexanes