1-Aminopiperidine → HCID 10205057, compound

HRID 1828598Notes

Reaction equation

HRID 1828598 reaction equation
[NH2:1][N:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[Cl:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[C:16]1[N:17]=[C:18]([C:29](OCC)=[O:30])[N:19]([CH3:28])[C:20]=1[C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=1>>[N:2]1([NH:1][C:29]([C:18]2[N:19]([CH3:28])[C:20]([C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)=[C:16]([C:10]3[CH:11]=[CH:12][C:13]([Cl:15])=[CH:14][C:9]=3[Cl:8])[N:17]=2)=[O:30])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 166581-AminopiperidineHCID 10179718HCID 10179718, compound

Product 1

HCID 10205057HCID 10205057, compound

Procedure

Using essentially the same procedure as Example 36, Step B (Method B), but using neat 1-aminopiperidine (3 mL), ethyl 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxylate (30 mg, 0.073 mmol) was converted to the title compound after purification by Prep TLC (40% ethyl acetate in hexanes).

Sources & evidence

ORD record
ord-3507160285d74f7691d3ca719bf3ace7
Source dataset
uspto-grants-2006_06
Patent number
US07057051B2

Reaction notes

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