Phenyl isocyanate → HCID 10182828, compound

HRID 1828601Notes

Reaction equation

HRID 1828601 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:10][C:11]1[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=1[C:18]1[N:19]=[CH:20][N:21]([CH3:30])[C:22]=1[C:23]1[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=1>>[C:1]1([NH:7][C:8]([C:20]2[N:21]([CH3:30])[C:22]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)=[C:18]([C:12]3[CH:13]=[CH:14][C:15]([Cl:17])=[CH:16][C:11]=3[Cl:10])[N:19]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 7672Phenyl isocyanateHCID 22066095HCID 22066095, compound

Product 1

HCID 10182828HCID 10182828, compound

Procedure

Using essentially the same procedure as Example 36, Method A, but using phenyl isocyanate (0.023 mL, 0.21 mmol), 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole (35 mg, 0.10 mmol) was converted to the title compound after purification by Prep TLC (25% ethyl acetate in hexanes). HPLC/MS: 456 (M+1), 458 (M+3); Rt=4.75 min.

Sources & evidence

ORD record
ord-3cff780950ab43409c30009ebef2da63
Source dataset
uspto-grants-2006_06
Patent number
US07057051B2

Reaction notes

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