Hexane → HCID 54717657, compound

Participants

Reaction Steps

19.22 g (50 mmol) XII were stirred for 3.5 h at room temperature with 2.75 g (63 mmol), 60%) NaH in 250 ml DMF. The mixture was then hydrolyzed with 50 ml saturated NH4Cl solution and the solvent was removed. The residue was taken up in 500 ml CHCl3, filtered, washed with water and dried over Na2SO4. Flash chromatography (250 g SiO2, n-hexane:ethyl acetate=5:1+1% acetic acid) gave 14.70 g (47 mmol, 95%) XIII.

Provenance & Evidence