Sodium Hydroxide → HCID 21028575, compound

HRID 1828645Notes

Reaction equation

HRID 1828645 reaction equation
C(OC([C:8]1[S:12][C:11]2[CH:13]=[C:14]([OH:18])[C:15]([OH:17])=[CH:16][C:10]=2[C:9]=1[OH:19])=O)CCC.[OH-].[Na+]>>[OH:19][C:9]1[C:10]2[CH:16]=[C:15]([OH:17])[C:14]([OH:18])=[CH:13][C:11]=2[S:12][CH:8]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 54717660HCID 54717660, compound

Product 1

HCID 21028575HCID 21028575, compoundYield 86%

Procedure

2.82 g (10 mmol) XIV and 6.00 g (150 mmol) NaOH were heated under reflux for 3.5 h in 300 ml degassed water. The still hot solution was then acidified with concentrated HCl to pH 1. The compound XV precipitating on cooling in an ice bath was removed and washed with a little diethylether. A yield of 1.57 g XV (8.6 mmol, 86%) was obtained.

Workup

  1. temperatureunder reflux for 3.5 h in 300 ml
  2. customdegassed water
  3. customThe compound XV precipitating
  4. temperatureon cooling in an ice bath
  5. customwas removed
  6. washwashed with a little diethylether

Sources & evidence

ORD record
ord-5670c4d3cf6e46e4afb0eb3f79ca7a9d
Source dataset
uspto-grants-2006_06
Patent number
US07060109B2

Reaction notes

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