HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → HCID 17937805, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Hydroxy-2,3-dihydro-1-benzofuran-3-one | HCID 9964142 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 17937805 | HCID 17937805 | 98% |
Reaction Steps
3.00 g (20 mmol) XVIII, 3.96 g (40 mmol) K2CO3 and 5.54 ml (50 mmol) bromoacetic acid ethyl ester were heated under reflux for 72 h in 150 ml tetrahydrofuran. After filtration, the solvent was removed. Flash chromatography (200 g SiO2, n-hexane:ethyl acetate=2:1) produced 4.63 g (19.6 mmol, 98%) XIX.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07060109B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-1c29ef35659044f586a51410615201bc |
| Source note | uspto-grants-2006_06 |