HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → HCID 17937806, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5-Hydroxy-2,3-dihydro-1-benzofuran-3-one | HCID 9964142 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 17937806 | HCID 17937806 | 73.3% |
Reaction Steps
900 mg (6.0 mmol) XVIII, 788 μl (7.2 mmol) orthoformic acid trimethyl ester and 57 mg (0.3 mmol) p-toluenesulfonic aid monohydrate were heated under reflux for 12 h in 70 ml methanol. The reaction was stopped by addition of saturated NaHCO3 solution and the solvent was removed. Subsequent flash chromatography (100 g SiO2, n-hexane:ethyl acetate=2:1, applied with ethanol) yielded 717 mg (4.4 mmol, 73%) XXI.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07060109B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-673a2acdc8c74e29a32ceda6da735d58 |
| Source note | uspto-grants-2006_06 |