1-Acetoxy-2-bromoethane → HCID 17937804, compound

Participants

Reaction Steps

164 mg (1.0 mmol) XXI and 48 mg (1.2 mmol, 60%) NaH were stirred for 30 mins. in 20 ml DMF at 0° C. 227 μl (2.0 mmol, 97%) 2-bromoethyl acetate were added to the resulting suspension which was then stirred for 72 h at room temperature. The reaction was quenched by addition of 3 ml saturated NH4Cl solution and the solvents were removed in vacuo. The residue was taken up in ethyl acetate and water, the aqueous phase was extracted twice with ethyl acetate and the combined organic phases were dried over Na2SO4. After column filtration (40 g SiO2, n-hexane:ethyl acetate=2:1, applied with ethyl acetate), XXII was obtained in a yield of 220 mg (0.88 mmol, 88%).

Provenance & Evidence