HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glyoxylic Acid → HCID 11833211, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glyoxylic Acid | HCID 760 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Benzenepropanoic acid, 3-(1,1-dimethylethyl)-4-hydroxy-, methyl ester | HCID 3084638 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 11833211 | HCID 11833211 | — |
Reaction Steps
3-(4-hydroxy-3-tert.butylphenyl) propionic acid methyl ester (10.0 g), glyoxylic acid (7.4 g of the 50% solution in water) and p-toluene sulphonic acid (40 mg) are heated in 40 ml ethylene chloride under nitrogen at reflux for 3 hours distilling off all water present and formed during the reaction. The reaction mixtures is washed with water, dried over magnesium sulphate and evaporated under reduced pressure to give 13.0 g of 7-tert.butyl-5-(2-methoxycarbonylethyl)-3-hydroxy-3H-benzofuran-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07060425B1 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-688995f89988411e96f1dd18517701b3 |
| Source note | uspto-grants-2006_06 |