Acetophenone → HCID 22057572, compound

HRID 1828668Notes

Reaction equation

HRID 1828668 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=O)[CH3:2].[NH2:10][NH2:11]>C(O)C>[C:4]1([CH2:1][CH:2]=[N+:10]=[N-:11])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 7410AcetophenoneHCID 9321Hydrazine

Product 1

HCID 22057572HCID 22057572, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Acetopheneone hydrazone: acetophenone (2.0 g, 16 mmol) is diluted in 16 ml of absolute ethanol and then hydrazine (2.3 ml, 48 mmol) is added. The mixture is heated to reflux temperature. After 2 h, the solvent is evaporated and the residue is taken up in ether (150 ml). The medium is washed with water (100 ml). After drying over Na2SO4, the ether is evaporated off. A pale yellow oil (1.5 g, 11 mmol, 69%) is obtained.

Workup

  1. temperatureThe mixture is heated
  2. temperatureto reflux temperature
  3. customthe solvent is evaporated
  4. washThe medium is washed with water (100 ml)
  5. dry with materialAfter drying over Na2SO4
  6. customthe ether is evaporated off

Sources & evidence

ORD record
ord-d2affbd66a5e4a199c90592b67175261
Source dataset
uspto-grants-2006_06
Patent number
US07060441B2

Reaction notes

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