Carbon tetrabromide → HCID 22057733, compound

Participants

Reaction Steps

To a solution of [4-(2-trifluoromethyl-biphenyl-4-ylsulfanylmethyl)-phenyl]-methanol (162 mg, 0.4327 mmol, 1 eq.) in anhydrous DCM (5 mL) is added PPh3 (148 mg, 0.5625 mmol, 1.3 eq). The mixture is stirred at room temperature for 5 min. at which point the reaction is cooled to 0° C. To the reaction mixture at 0° C. is added a solution of CBr4 (187 mg, 0.5625 mmol, 1.3 eq.) in anhydrous DCM (2 mL). The reaction is allowed to slowly warm to room temperature and is stirred for 12 h. The reaction mixture is applied directly to silica gel chromatography (6:1 hexanes/EtOAc) to give 4-(4-bromomethyl-benzylsulfanyl)-2-trifluoromethyl-biphenyl.

Provenance & Evidence