Lithium hydroxide, monohydrate → HCID 22057727, compound

Participants

Reaction Steps

To a solution of 1-[4-(2-trifluoromethyl-biphenyl-4-ylsulfanylmethyl)-benzyl]-azetidine-3-carboxylic acid methyl ester (129 mg, 0.2736 mmol, 1 eq.) in a mixture of MeOH (5 mL) and H2O (0.5 mL) is added LiOH—H2O (23 mg, 0.5472 mmol, 2 eq.). The mixture is stirred at room temperature for 3 h. After concentration, the crude product is purified by preparative RP LC-MS to give 1-[4-(2-Trifluoromethyl-biphenyl-4-ylsulfanylmethyl)-benzyl]-azetidine-3-carboxylic acid: 1H NMR (CD3OD, 400 MHz) δ7.61 (s, 1H), 7.60 (d, 1H), 7.56 (d, 2H), 7.46–7.39 (m, 6H), 7.29 (d, 2H), 4.42 (s, 2H), 4.35 (s, 2H), 4.31 (d, 4H), 3.73–3.61 (m, 1H); MS (ES+): (458.1, M+1)+.

Provenance & Evidence