反应详情

The obtained 1-cyclohexyl-4-(4-methoxy-benzyloxymethyl)-2-trifluoromethyl-benzene is dissolved in a mixture of TFA and DCM (8 mL, 1:1 v/v). After stirring at room temperature for 2 h, all volatile materials are evaporated and the residue obtained is dissolved in EtOAc and washed with saturated aqueous NaHCO3. The organic layer is separated, washed with saturated aqueous NaCl and dried over Na2SO4. After concentration, the residue is purified by silica gel chromatography (20% ethyl acetate in hexanes) to give (4-cyclohexyl-3-trifluoromethyl-phenyl)-methanol as a colorless oil.

1. customall volatile materials are evaporated
2. customthe residue obtained
3. washwashed with saturated aqueous NaHCO3
4. customThe organic layer is separated
5. washwashed with saturated aqueous NaCl
6. dry with materialdried over Na2SO4
7. concentrationAfter concentration
8. customthe residue is purified by silica gel chromatography (20% ethyl acetate in hexanes)