Morpholine → HCID 22057967, compound

HRID 1828744Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:16]=[CH:15][N:14]=[C:13](Cl)[CH:12]=2)=[O:10])=[CH:4][C:3]=1[NH:18][C:19]([C:21]1[CH:26]=[CH:25][N:24]=[C:23](Cl)[CH:22]=1)=[O:20].[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)[CH:12]=2)=[O:10])=[CH:4][C:3]=1[NH:18][C:19]([C:21]1[CH:26]=[CH:25][N:24]=[C:23]([N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)[CH:22]=1)=[O:20]

Participants

Reactant 2

HCID 8083Morpholine

HCID 22058010HCID 22058010, compound

Product 1

HCID 22057967HCID 22057967, compoundYield 84%

Procedure

Using an analogous procedure to that described in Example 21, N-[2-chloro-5-(2-chloropyrid-4-ylcarbonylamino)phenyl]-2-chloropyridine-4-carboxamide was reacted with morpholine to give the title compound in 84% yield; NMR Spectrum: (DMSOd6) 3.52 (m, 8H), 3.73 (m, 8H), 7.12 (m, 2H), 7.26 (d, 2H), 7.55 (d, 1H), 7.73 (d, 1H), 8.04 (s, 1H), 8.3 (m, 2H), 10.21 (s, 1H), 10.48 (s, 1H); Mass Spectrum: M+H+ 523.

Sources & evidence

ORD record: ord-128b9084569a4dc4b8b2feded9a2fbf8
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07060700B2

Reaction notes

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