2,4,6-Trimethylpyridine → HCID 86597653, compound

Participants

Reaction Steps

The resin-bound, free amine or hydrazine (0.389 mmol) is washed with NMP (5×5 ml, 3-minutes each time). A solution of the suitable Fmoc-protected amino acid or of a carboxylic acid unit (0.779 mmol, 2 eq), HATU (296 mg, 0.779 mmol, 2 eq) and HOAt (106 mg, 0.779 mmol, 2 eq) in NMP (5 ml) is then added to the resin. Finally, sym-collidine (1027 μl, 7.79 mmol, 20 eq) is added, and the resin is shaken overnight. The resin is then washed with NMP (5×5 ml, 3 minutes each time), and the coupling step is repeated with the same reagents, amounts and reaction time. The resin is subsequently washed with NMP (5×5 ml, 3 minutes each time).

Provenance & Evidence