Malonic Acid → (1,2,3,4-Tetrahydroisoquinolin-1-yl)acetic acid

Participants

Reaction Conditions

Reaction Steps

3,4-Dihydroisoquinoline (147) (2.2 g, 16.77 mmol) and malonic acid (1.94 g, 16.77 mmol) were mixed at room temperature and heated at 120° C. for 1 hour in an oil bath. The mixture was then allowed to cool to room temperature, and the product was recrystallised from methanol (150 ml). Drying gave a colourless solid (1.52 g, 7.99 mmol, 48%).

Provenance & Evidence