2,4,6-Trimethylpyridine → HCID 131725787, compound

Participants

Reaction Steps

0.072 mmol of A is washed with DMF (1×2 ml). The compound is subsequently deprotected twice using 20% of piperidine in DMF (2×2 ml), firstly for 5 minutes and then for 15 minutes, and washed with DMF (6×2 ml). An approximately 0.1M solution of 2.5 equivalents (based on the resin loading, 0.18 mmol) of Fmoc-glycine, 2.4 equivalents (0.17 mmol) of HATU and 30 equivalents (2.16 mmol) of sym-collidine in dry DMF is added to the resin-bound free amine, and the mixture is shaken at room temperature for 90 minutes. The reaction is terminated by washing in DMF (6×2 ml).

Provenance & Evidence