N-(3-Methoxy-4-oxazol-5-yl-phenyl)-N''-m-tolyl-malonamide → 3-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-3-oxopropanoic acid

HRID 1828782Notes

Reaction equation

HRID 1828782 reaction equation
C[O:2]C1C=C(NC(=O)C(O)=O)C=CC=1C1OC=NC=1.[CH3:20][O:21][C:22]1[CH:23]=[C:24]([NH:33][C:34](=[O:46])[CH2:35][C:36](NC2C=CC=C(C)C=2)=[O:37])[CH:25]=[CH:26][C:27]=1[C:28]1[O:32][CH:31]=[N:30][CH:29]=1>>[CH3:20][O:21][C:22]1[CH:23]=[C:24]([NH:33][C:34](=[O:46])[CH2:35][C:36]([OH:37])=[O:2])[CH:25]=[CH:26][C:27]=1[C:28]1[O:32][CH:31]=[N:30][CH:29]=1

Participants

3

Reactant 2

HCID 10361468N-(3-Methoxy-4-oxazol-5-yl-phenyl)-N''-m-tolyl-malonamideHCID 22058527N-[3-methoxy-4-(5-oxazolyl)phenyl]oxalamic acid

Product 1

HCID 220584973-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-3-oxopropanoic acid

Procedure

56A was prepared from 55 by a route analogous to that used for the preparation of 5A. LC/MS: ret. timeA=2.611 min., MS (M+H)+=277. 56B. Preparation of N-[3-Methoxy-4-(5-oxazolyl)phenyl]-N′-(3-methylphenyl) propanediamide

Workup

  1. customtimeA=2.611 min., MS (M+H)+=277

Sources & evidence

ORD record
ord-020bbbe10b584339bd7885048be34076
Source dataset
uspto-grants-2006_06
Patent number
US07060720B2

Reaction notes

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