Hydrochloric Acid → HCID 22058584, compound

Participants

Reaction Steps

4-Chloro-1-(2-chloro-4-(1-pentyloxy)benzyl)-2-methyl-1H-imidazole-5-carbaldehyde (400 mg) was dissolved in t-butanol (8 ml), and 2-methyl-2-butene (355 mg) and aqueous sodium dihydrogenphosphate (135 mg) solution (2 ml) were added. To this reaction mixture was added sodium chlorite (356 mg) over 2 min and the mixture was stirred at room temperature for 24 hr. 1N Hydrochloric acid was added under ice-cooling to adjust to pH 4. Water (20 ml) was added and the precipitated crystals were collected by filtration. The crystals were dried by heating under reduced pressure to give 4-chloro-1-(2-chloro-4-(1-pentyloxy)benzyl)-2-methyl-1H-imidazole-5-carboxylic acid (387 mg) as colorless crystals.

Provenance & Evidence