Ethyl Acetate → HCID 9932550, compound

Participants

Reaction Steps

A solution of 2 g of 7-(3-chloro-4-methoxybenzylamino)-5-chloromethyl-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine in 10 ml of DMF is treated with 5 ml of 3-aminopropanol and stirred at room temperature for two hours. It is then diluted with water and extracted with ethyl acetate. The oily product obtained after customary work-up is dissolved in alcoholic HCl and treated with ethyl acetate until turbidity. The precipitated crystals are filtered off with suction and recrystallized from isopropanol/ethyl acetate. 3.1 g of 7-(3-chloro-4-methoxybenzylamino)-5-(3-hydroxypropylaminomethyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine are obtained in the form of its dihydrochloride.

Provenance & Evidence