Phosphoric Acid → HCID 22059084, compound

Participants

Reaction Conditions

Reaction Steps

Sodium hydride (5.0 g, 0.114 mole) and 4-phenylphenol (15.3 g, 0.09 mol) were stirred at 0° C. in 75 mL of dimethyl formamide (hereinafter “DMF”) for 2 h. Ethyl 4-chloroacetoacetate (5.0 g, 0.03 mol) in DMF (75 mL) was added. The mixture was stirred for 1 h at 0° C. and for 12 h at room temperature, then neutralized with 50% phosphoric acid and extracted with dichloromethane. The product was purified by silica gel chromatography using (8:2) toluene:ethanol as the mobile phase.

Provenance & Evidence