Boron tribromide → HCID 22059409, compound

Participants

Reaction Conditions

Reaction Steps

A stirred suspension of 3-(4-methoxybenzyl)-2-pyrazolin-5-one 2.5 mmol in dichloromethane 100 ml cooled at −78° C., was treated with boron tribromide 7.5 ml (1M in dichloromethane). After 1 hour at −78° C. the reaction mixture was stirred at room temperature for 12 hours. The mixture was quenched with water 50 ml. The aqueous phase was separated out, and basified with 5% sodium bicarbonate solution. The formed precipitate was filtered and crystallized from methanol.

Provenance & Evidence