Sulfuric Acid → HCID 22059131, compound

HRID 1828896Notes

Reaction equation

HRID 1828896 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[NH:4][C:3]=1[CH:8]=[O:9].O[CH2:11][NH:12][C:13](=[O:18])[C:14]([F:17])([F:16])[F:15].S(=O)(=O)(O)O>>[CH3:1][C:2]1[C:6]([CH2:11][NH:12][C:13](=[O:18])[C:14]([F:17])([F:16])[F:15])=[C:5]([CH3:7])[NH:4][C:3]=1[CH:8]=[O:9]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 2704653,5-Dimethyl-1H-pyrrole-2-carbaldehydeHCID 30849312,2,2-Trifluoro-N-(hydroxymethyl)acetamide

Product 1

HCID 22059131HCID 22059131, compound

Procedure

A mixture of 3,5-dimethylpyrrole-2-carboxaldehyde (2.6 g, 0.02 mol) and N-(hydroxymethyl)trifluoroacetamide (3 g, 0.02 mol) was added in portionwise to sulfuric acid (15 ml) keeping the temperature below 10° C. The mixture of reaction was allowed to warm at room temperature for 4 h. The reaction was poured into ice-water (100 ml), the precipitated solid was filtered and washed with water. The white solid (yield, 78%) was used without further purification. M.p. 200° C.

Workup

  1. customthe temperature below 10° C
  2. additionThe mixture of reaction
  3. filtrationthe precipitated solid was filtered
  4. washwashed with water
  5. customThe white solid (yield, 78%)
  6. customwas used without further purification

Sources & evidence

ORD record
ord-8c9b781aa1624f6ab0f426e53b322278
Source dataset
uspto-grants-2006_06
Patent number
US07060822B1

Reaction notes

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