Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | Tert-butoxycarbonylalanine | HCID 85082 | — |
| Reactant | (S)-(+)-Methyl indoline-2-carboxylate | HCID 7020378 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 11439448 | HCID 11439448 | — |
Reaction Steps
There are introduced into a reactor, with stirring, 2.13 kg of methyl(2S)-2,3-dihydroindole-2-carboxylate, 1 kg of triethylamine, 30 litres of tetrahydrofuran and then, after 10 minutes' stirring at room temperature, 1.9 kg of N-[tert-butyloxycarbonyl]-(S)-alanine and 2 kg of dicyclohexylcarbodiimide. The heterogeneous mixture is then stirred at room temperature for 6 hours, and is subsequently cooled to 0° C. and filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07060842B2 |
|---|
| Source dataset | uspto-grants-2006_06 |
|---|
| ORD ID | ord-49236bcd7962412f9cc400bac6d0e01a |
|---|
| Source note | uspto-grants-2006_06 |
|---|
