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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 18290Generated: October 30, 2026

1,3-dimethyl-1H-indole-2-carbaldehyde → 3-(methylaminomethyl)-1,2,7-trimethyl-1H-indole

https://huagongshe.com/reaction/18290

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-dimethyl-1H-indole-2-carbaldehydeHCID 2771468—
Reactant1,2,7-trimethyl-1H-indole-3-carboxaldehydeHCID 17604458—
ReactantMethyl 2-((5-bromopyridin-2-yl)amino)acetateHCID 22139049—
Product3-(methylaminomethyl)-1,2,7-trimethyl-1H-indoleHCID 1100900571%

Reaction Steps

According to the procedure of Preparation 13 (c) except substituting 1,2,7-trimethyl-1H-indole-3-carboxaldehyde for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (570 mg, 71%) was obtained as an oil which slowly crystallized: MS (ES) m/e 405.4 (2M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07741339B2
Source datasetuspto-grants-2010_06
ORD IDord-3ca52a7348c247bbbc65c69a799f1486
Source noteuspto-grants-2010_06