Water → HCID 69659216, compound

HRID 1829015Notes

Reaction equation

HRID 1829015 reaction equation
Br[CH2:2][C:3]([NH:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[CH2:11][O:10][C:9]2=[C:15]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([Cl:24])[CH:22]=2)[NH:17][C:16]1=[O:25])=[O:4].[OH2:26]>N1CCOCC1>[Cl:24][C:21]1[CH:22]=[C:23]2[C:18](=[CH:19][CH:20]=1)[NH:17][C:16](=[O:25])[C:15]2=[C:9]1[C:8]2[C:12](=[CH:13][CH:14]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:5]3[CH2:6][CH2:14][O:26][CH2:2][CH2:3]3)[CH:7]=2)[CH2:11][O:10]1

Participants

4

Reactant 2

HCID 962WaterHCID 69659377HCID 69659377, compound

Product 1

HCID 69659216HCID 69659216, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 8083MorpholineSolvent

Conditions

Temperature
40 °C

Procedure

A mixture of 2-bromo-N-[3-(5-chloro-2-oxo-1,2-dihydro-indol-3-ylidene)-1,3-dihydro-isobenzofuran-5-yl]-acetamide (63 mg, 0.15 mmol) in morpholine (1 ml) was stirred at 40° C. under nitrogen for 40 minutes. The mixture was poured into water (75 ml). The solid was filtered, washed with water and dried under vacuum to give N-[3-(5-chloro-2-oxo-1,2-dihydro-indol-3-ylidene)-1,3-dihydro-isobenzofuran-5-yl]-2-morpholin-4-yl-acetamide as a yellow solid (60 mg, 94%).

Workup

  1. filtrationThe solid was filtered
  2. washwashed with water
  3. customdried under vacuum

Sources & evidence

ORD record
ord-46970bce80af4d3a92e544e1ef2ae51e
Source dataset
uspto-grants-2006_06
Patent number
US07060844B2

Reaction notes

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