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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 18291Generated: October 29, 2026

7-chloro-1H-indole-3-carbaldehyde → 7-chloro-3-(methylaminomethyl)-1H-indole

https://huagongshe.com/reaction/18291

Reaction equation

Participants

RoleNameHCIDCharge
Reactant7-chloro-1H-indole-3-carbaldehydeHCID 643958—
Reactant1,3-dimethyl-1H-indole-2-carbaldehydeHCID 2771468—
ReactantMethyl 2-((5-bromopyridin-2-yl)amino)acetateHCID 22139049—
Product7-chloro-3-(methylaminomethyl)-1H-indoleHCID 2213900492%

Reaction Steps

According to the procedure of Preparation 13 (c), except substituting 7-chloro-1H-indole-3-carboxaldehyde for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (440 mg, 92%) was obtained as an off white solid: MS (ES) m/e 195.2 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07741339B2
Source datasetuspto-grants-2010_06
ORD IDord-c18916cc259f43608802d32b2c2f8f32
Source noteuspto-grants-2010_06