Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 4-Chloroquinoline | HCID 69140 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Piperazin-1-yl-quinoline | HCID 1534386 | 105.9% |
Reaction Steps
Piperazine (13.2 g) was melted by heating at 140° C., and 4-chloroquinoline (2.5 g) was added thereto. The mixture was stirred at 140° C. for 30 min. The reaction mixture was added to iced water, and the mixture was extracted with chloroform to give 1-(4-quinolyl)piperazine (3.45 g) as a pale-yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07060722B2 |
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| Source dataset | uspto-grants-2006_06 |
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| ORD ID | ord-15fcb9b00d0549c2be35d93083c73f96 |
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| Source note | uspto-grants-2006_06 |
|---|
