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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1829128Generated: November 1, 2026

Piperazine → 6-(Piperazin-1-yl)pyridine-3-carboxamide

https://huagongshe.com/reaction/1829128

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperazineHCID 4837—
Reactant6-ChloronicotinamideHCID 80456—
Product6-(Piperazin-1-yl)pyridine-3-carboxamideHCID 220289886.2%

Reaction Steps

Using 6-chloronicotinamide (5.00 g) and piperazine (27.6 g), and by reaction in the same manner as in Example 196 (1) at 100° C., 1-(5-carbamoyl-2-pyridyl)piperazine (0.41 g) was obtained as a yellow powder.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07060722B2
Source datasetuspto-grants-2006_06
ORD IDord-7062f6fe1f9644d89dbb560ac2133724
Source noteuspto-grants-2006_06