HCID 67506920, compound → HCID 67506998, compound

HRID 1829155Notes

Reaction equation

C(OC([N:8]1[CH2:12][C@@H:11]([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[N:22]=[C:21]([C:29](=[O:31])[NH2:30])[CH:20]=3)[CH2:15][CH2:14]2)[CH2:10][C@H:9]1[C:32]([N:34]1[CH2:38][CH2:37][S:36][CH2:35]1)=[O:33])=O)(C)(C)C.[ClH:39].Cl.Cl.COC(C1C=C(N2CCN([C@@H]3CN[C@H](C(N4CCSC4)=O)C3)CC2)C2C(=CC=CC=2)N=1)=O>>[ClH:39].[ClH:39].[ClH:39].[C:29]([C:21]1[CH:20]=[C:19]([N:16]2[CH2:17][CH2:18][N:13]([C@@H:11]3[CH2:12][NH:8][C@H:9]([C:32]([N:34]4[CH2:38][CH2:37][S:36][CH2:35]4)=[O:33])[CH2:10]3)[CH2:14][CH2:15]2)[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[N:22]=1)(=[O:31])[NH2:30]

Participants

Reactant 2

HCID 67506920HCID 67506920, compound

HCID 67508184HCID 67508184, compound

Product 1

HCID 67506998HCID 67506998, compound

Procedure

Using 3-{(2S,4S)-1-tert-butoxycarbonyl-4-[4-(2-carbamoyl-4-quinolyl)-1-piperazinyl]-2-pyrrolidinylcarbonyl}-1,3-thiazolidine [product of Example 262 (3), 1.05 g], and in the same manner as in Example 186 (2), the title compound (696 mg) was obtained as a brown powder.

Sources & evidence

ORD record: ord-d067e1c17ac24955a03e186fdfe8d38b
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07060722B2

Reaction notes

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