Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | O-Toluidine | HCID 7242 | — |
| Reactant | Ethyl 4,4,4-trifluoroacetoacetate | HCID 67793 | — |
| Solvent | Phosphoric Acid | HCID 1004 | — |
| Product | HCID 178423901 | HCID 178423901 | 17.4% |
Reaction Steps
2-Methylaniline (5.00 g) was dissolved in 75% phosphoric acid (20 mL), and ethyl trifluoroacetoacetate (8.60 g) was dropwise added thereto at 105° C. The mixture was stirred at 105° C. for 5.5 hr. After allowing to cool, the reaction mixture was added to water. The precipitated solid was collected by filtration to give 2-trifluoromethyl-4-hydroxy-8-methylquinoline (1.84 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07060722B2 |
|---|
| Source dataset | uspto-grants-2006_06 |
|---|
| ORD ID | ord-8145cb04aa234de6a4b87cef085dc5ea |
|---|
| Source note | uspto-grants-2006_06 |
|---|
