反应详情

Methyl isocyanate (8.94 g, 157 mmol) was added to a solution of 1-benzyl-4-piperidinol (10 g, 52.3 mmol) in chloroform (80 ml), and the reaction stirred under reflux for 16 hours. The cooled mixture was concentrated under reduced pressure, the residual solid was triturated from 40–60 petroleum ether, and the product filtered and dried to afford the title compound as a white solid, 1 g. m.p.—106–108° C.

1. temperatureunder reflux for 16 hours
2. concentrationThe cooled mixture was concentrated under reduced pressure
3. customthe residual solid was triturated from 40–60 petroleum ether
4. filtrationthe product filtered
5. customdried