Dichloromethane → HCID 22061300, compound

HRID 1829187Notes

Reaction equation

HRID 1829187 reaction equation
[N:1]1([CH:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:20]CCl>>[ClH:20].[NH:10]1[CH2:11][CH2:12][CH:7]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)[CH2:8][CH2:9]1

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 14571198tert-Butyl 4-(morpholin-4-yl)piperidine-1-carboxylate

Product 1

HCID 22061300HCID 22061300, compound

Conditions

Temperature
0 °C

Procedure

Hydrogen chloride was bubbled through an ice-cooled solution of tert-butyl 4-(4-morpholinyl)-1-piperidinecarboxylate (J.O.C. 1990; 55(8); 2552) (6.5 g, 24 mmol) in dichloromethane (100 ml), and the solution then stirred at 0° C. for 2 hours. The reaction was degassed under nitrogen, allowed to warm to room temperature, and evaporated under reduced pressure to afford the title compound as a white solid, 5.91 g.

Workup

  1. customHydrogen chloride was bubbled through an ice-
  2. customThe reaction was degassed under nitrogen
  3. temperatureto warm to room temperature
  4. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-638f1408cb5048beac50e23aa42c85ff
Source dataset
uspto-grants-2006_06
Patent number
US07060836B2

Reaction notes

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