4-Aminopyridine → HCID 22061296, compound

Participants

Reaction Steps

A mixture of 4-aminopyridine (25 g, 266 mmol) and ethylisocyanoacetate (35 g, 271 mmol) in N,N-dimethylformamide (250 ml) was heated under reflux for 90 minutes, and allowed to cool. The resulting precipitate was filtered off, and the filtrate heated under reflux for a further 5 hours. The cooled mixture was concentrated under reduced pressure, and the residue triturated with hot ethanol (500 ml). The resulting solid was filtered, and recrystallised from N,N-dimethylformamide to afford the title compound as a yellow crystalline solid, 47.8 g.

Provenance & Evidence