4-Methylmorpholine → HCID 54304839, compound

Participants

Reaction Steps

To DMF(2 ml) solution of D-Ser(Bzl)-OMe hydrochloride(141 mg) and 3-(4-oxo-2,3-dihydro-1,5-benzothiazepin-5-yl)-propionic acid(138 mg),N-methyl morpholine(61 mg), HOBt(92 mg) and EDC(125 mg) were added under cooling on ice-water and then stirring is continued at room temperature overnight. After reaction, reaction mixture was poured into saturated sodium hydrogen carbonate solution(20 ml) and then extracted with ethyl acetate. Ethyl acetate layer was dried on anhydrous sodium sulfate and then evaporated to dryness. Title compound(270 mg) was isolated by using silica gel chromatography(CHCl3:MeOH=100:1).

Provenance & Evidence