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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1829644생성일: 2026년 10월 25일

4-Fluoro-phenylboric acid → 6-[3,5-Bis(trifluoromethyl)benzyl]-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-2-(methylthio)-5-oxopyrimido[4,5-b][1,5]diazocine

https://huagongshe.com/reaction/1829644

반응식

참여 물질

역할이름HCID투입량
반응물4-Fluoro-phenylboric acidHCID 21939771—
반응물6-[3,5-Bis(trifluoromethyl)benzyl]-4-chloro-5,6,7,8,9,10-hexahydro-2-(methylthio)-5-oxopyrimido[4,5-b][1,5]diazocineHCID 22053599—
생성물6-[3,5-Bis(trifluoromethyl)benzyl]-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-2-(methylthio)-5-oxopyrimido[4,5-b][1,5]diazocineHCID 2205357291.2%

반응 단계

In a similar manner to Reference Example 10, 6-[3,5-bis(trifluoromethyl)benzyl]-4-chloro-5,6,7,8,9,10-hexahydro-2-(methylthio)-5-oxopyrimido[4,5-b][1,5]diazocine (Compound of Reference Example 7; 2.43 g) was reacted with 4-fluorophenylboric acid (840 mg) to obtain 6-[3,5-bis(trifluoromethyl)benzyl]-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-2-(methylthio)-5-oxopyrimido[4,5-b][1,5]diazocine (2.49 g, 91%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07064119B2
출처 데이터셋uspto-grants-2006_06
ORD IDord-edfe1335e2404e6e9594357b08766185
출처 메모uspto-grants-2006_06