HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Piperazinecarboxaldehyde → HCID 22053581, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Piperazinecarboxaldehyde | HCID 82191 | — |
| Reactant | 6-[3,5-Bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-2-(methylsulfonyl)-5-oxopyrimido[4,5-b][1,5]diazocine | HCID 22053591 | — |
| Product | HCID 22053581 | HCID 22053581 | 6.2% |
Reaction Steps
In a similar manner to Example 1, 6-[3,5-bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-2-(methylsulfonyl)-5-oxopyrimido[4,5-b][1,5]diazocine (Compound of Reference Example 19; 85.9 mg) was reacted with 1-formylpiperazine(20.6 mg) to obtain 6-[3,5-bis(trifluoromethyl)benzyl]-2-(4-formylpiperazine-1-yl)-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-5-oxopyrimido[4,5-b][1,5]diazocine (5.6 mg, 6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07064119B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-688fb17f5767481bad1ad299a2051c6d |
| Source note | uspto-grants-2006_06 |