Imidazole → HCID 22053584, compound

Participants

Reaction Steps

In a similar manner to Example 1, 6-[3,5-bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-2-(methylsulfonyl)-5-oxopyrimido[4,5-b][1,5]diazocine (Compound of Reference Example 19; 85.9 mg) was reacted with sodium salt of imidazole (16.2 mg) to obtain 6-[3,5-bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-2-(imidazole-1-yl)-4-(2-methylphenyl)-5-oxopyrimido[4,5-b][1,5]diazocine (61.0 mg, 73%).

Provenance & Evidence