N,N-Dimethylpiperidin-4-amine → 6-[3,5-Bis(trifluoromethyl)benzyl]-2-[4-(dimethylamino)piperidine-1-yl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-5-oxopyrimido[4,5-b][1,5]diazocine

Participants

Reaction Steps

In a similar manner to Example 1, 6-[3,5-bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-2-(methylsulfonyl)-5-oxopyrimido[4,5-b][1,5]diazocine (Compound of Example 19; 85.9 mg) was reacted with 4-(dimethylamino)piperidine (23.1 mg) to obtain 6-[3,5-bis(trifluoromethyl)benzyl]-2-[4-(dimethylamino)piperidine-1-yl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-5-oxopyrimido[4,5-b][1,5]diazocine (80.5 mg, 86%).

Provenance & Evidence