1-(Piperidin-4-yl)pyrrolidin-2-one → 6-[3,5-Bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-5-oxo-2-[4-(2-oxopyrrolidine-1-yl)piperidine-1-yl]pyrimido[4,5-b][1,5]diazocine

Participants

Reaction Steps

In a similar manner to Example 1, 6-[3,5-bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-2-(methylsulfonyl)-5-oxopyrimido[4,5-b][1,5]diazocine (Compound of Reference Example 19; 85.9 mg) was reacted with 4-(2-oxopyrrolidine-1-yl)piperidine (30.3 mg) to obtain 6-[3,5-bis(trifluoromethyl)benzyl]-5,6,7,8,9,10-hexahydro-4-(2-methylphenyl)-5-oxo-2-[4-(2-oxopyrrolidine-1-yl)piperidine-1-yl]pyrimido[4,5-b][1,5]diazocine (96.0 mg, 97%).

Provenance & Evidence