反应详情

温度

65 °C

A mixture of 37 gms (0.1 mole) of (40% solution) 2-mercaptopyridine N-oxide, sodium salt and 19.5 gms (0.1 mole) 2,6-dichlorobenzylchloride in 200 ml ethanol is warmed to 65° C. for thirty minutes, cooled and filtered. The filter cake is washed thoroughly with water and finally with 40 ml of acetone. Vacuum drying of the cake yields 25.3 gms (92% theory) of product, 2-(2,6-dichlorophenylmethylthio)pyridine N-oxide. Melting point 240°–241° C. Structure confirmed by IR.

1. temperaturecooled
2. filtrationfiltered
3. washThe filter cake is washed thoroughly with water and finally with 40 ml of acetone
4. customVacuum drying of the cake