HCID 11381597, compound → HCID 45091361, compound

HRID 1829757Notes

Reaction equation

HRID 1829757 reaction equation
C(OC([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[CH2:16][O:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][O:19]1)=O)C1C=CC=CC=1>C(O)C>[O:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH:18]1[O:17][CH2:16][C@@H:12]1[CH2:13][CH2:14][CH2:15][NH:11]1

Participants

3

Reactant 1

HCID 11381597HCID 11381597, compound

Product 1

HCID 45091361HCID 45091361, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(S)-2-(Tetrahydro-pyran-2-yloxymethyl)-pyrrolidine-1-carboxylic acid benzyl ester (445 mg, 1.39 mmol) was dissolved in ethanol (9 mL) and hydrogenated at atmospheric pressure and room temperature in the presence of 10% paladium on charcoal (10 mg). After 16 h the reaction mixture was passed through a filter aid and evaporated to afford the title compound which was used without further purification (255 mg, 99%). Black liquid, ISP-MS: m/e=186.3 ([M+H]+).

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-45d723bab52b49879cba485d93ef00d3
Source dataset
uspto-grants-2006_06
Patent number
US07064134B2

Reaction notes

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