Ammonium Hydroxide → HCID 69527824, compound

Participants

Reaction Steps

A mixture of ethyl 1-{(1R,2S)-1-[(3,4-dichlorophenoxy)methyl]-2-hydroxypropyl}-1H-imidazole-4-carboxylate (0.23 g), 28% ammonium hydroxide (12 mL) and 1,2-dimethoxyethane (6 mL) was heated at 100° C. in the stainless steel bottle for 24 hours. After cooling, the reaction mixture was concentrated in vacuo and the residue was purified by column chromatography on silica gel (gradient elution; 20:1 to 10:1 chloroform-methanol) to give the product, which was recrystallized from 1:5 n-hexane-ethyl acetate (12 mL) to give 1-{(1R,2S)-1-[(3,4-dichlorophenoxy)methyl]-2-hydroxypropyl}-1H-imidazole-4-carboxamide (81) (0.13 g).

Provenance & Evidence