HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (4R)-4,8-Dimethylnonanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl (4R)-4,8-dimethylnonanoate | HCID 71406104 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (4R)-4,8-Dimethylnonanoic acid | HCID 71351570 | — |
Reaction Steps
(4R)-4,8-dimethyl nonanoic acid t-butyl ester in 25 mL CH2Cl2 at 0° C. was treated with TFA (6 mL). The mixture was allowed to reach ambient temperature and stir overnight. The solvent was removed by rotary evaporation, and the mixture was purified by silica gel chromatography (95/5 hexane/EtOAc) to give 0.962 g (4R)-4,8-dimethyl nonanoic acid. m/z 185 (M−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07064147B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-fc3f4df650e14fc6ac4203787404fd1e |
| Source note | uspto-grants-2006_06 |