反应详情

1,1-bis(4-fluorophenyl)-1,2-propanediamine(50 mg) was dissolved in methanol(1 mL), and to the solution was added 3-cyanobenzeneimidic acid methyl ester (75 mg). The mixture was stirred at room temperature for 24 hrs. After chloroform (5 ml) was added to the reaction mixture, insolubles were removed by filtration. After concentrating the filtrate in vacuo, the obtained residue was purified by silica gel column chromatography (C-300; hexane:ethyl acetate=3:1→1:1) to give the objective compound (10 mg).

1. customwere removed by filtration
2. concentrationAfter concentrating the filtrate in vacuo
3. customthe obtained residue was purified by silica gel column chromatography (C-300; hexane:ethyl acetate=3:1→1:1)