Trifluoroacetic acid → [5-(4-Amino-4-methyl-piperidin-1-ylmethyl)-pyrrolo[2,1-f][1,2,4]triazin-4-yl]-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-amine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Trifluoroacetic acid	HCID 6422	—
Edukt	N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-5-((4-aminopiperidin-1-yl)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine	HCID 11698674	—
Edukt	4-Methylpiperidin-4-amine	HCID 21090445	—
Edukt	(5-Benzenesulfinylmethyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-amine	HCID 22055282	—
Lösungsmittel	Methanol	HCID 887	—
Produkt	[5-(4-Amino-4-methyl-piperidin-1-ylmethyl)-pyrrolo[2,1-f][1,2,4]triazin-4-yl]-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-amine	HCID 22055277	—

Reaktionsschritte

The title compound was prepared from 7B and excess 4-amino-4-methylpiperidine (WO 9732880) by a route analogous to that used for the preparation of 7C. Analytical HPLC retention time=1.43 min. (YMC Xterra S7 C 18, 3.0×50 mm column, 10–90% aqueous methanol over 2 minutes containing 0.1% TFA, 5 mL/min, monitoring at 220 nm) and a LC/MS M++1=495.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07064203B2
Quelldatensatz	uspto-grants-2006_06
ORD ID	ord-d3fb79270a7549d2860f1e52084580c4
Quellennotiz	uspto-grants-2006_06