Piperazine → [3-Chloro-4-(3-fluoro-benzyloxy)-phenyl]-(5-piperazin-1-ylmethyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-amine

HRID 1829919Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1829919
C1(S([CH2:9][C:10]2[CH:11]=[CH:12][N:13]3[C:18]=2[C:17]([NH:19][C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[CH:29]=4)=[C:22]([Cl:35])[CH:21]=2)=[N:16][CH:15]=[N:14]3)=O)C=CC=CC=1.[NH:36]1[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1.NC1CCN(CC2C=CN3C=2C(NC2C=CC(OCC4C=CC=C(F)C=4)=C(Cl)C=2)=NC=N3)CC1.C(O)(C(F)(F)F)=O>CO>[Cl:35][C:22]1[CH:21]=[C:20]([NH:19][C:17]2[C:18]3=[C:10]([CH2:9][N:36]4[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]4)[CH:11]=[CH:12][N:13]3[N:14]=[CH:15][N:16]=2)[CH:25]=[CH:24][C:23]=1[O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[CH:29]=1

Komponenten

6

Edukt 4

HCID 4837PiperazineHCID 6422Trifluoroacetic acidHCID 11698674N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-5-((4-aminopiperidin-1-yl)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amineHCID 22055282(5-Benzenesulfinylmethyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-amine

Produkt 1

HCID 22055285[3-Chloro-4-(3-fluoro-benzyloxy)-phenyl]-(5-piperazin-1-ylmethyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The title compound was prepared from 7B and excess piperazine by a route analogous to that used for the preparation of 7C. Analytical HPLC retention time=1.68 min. (YMC Xterra S7 C18, 3.0×50 mm column, 10–90% aqueous methanol over 2 minutes containing 0.1% TFA, 5 mL/min, monitoring at 220 nm) and a LC/MS M++1=467.

Quellen und Nachweise

ORD-Eintrag
ord-86167aa1b2a242d3a8a2ffa6c9e57196
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07064203B2

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