Potassium Carbonate → HCID 22055255, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-4-nitro-phenol (202 mg, 1.16 mmol), 2-chloromethyl-quinoline hydrochloride (224 mg, 1.04 mmol), K2CO3 (354 mg, 2.55 mmol) in CH3CN (3.6 ml) was heated at 70° C. for 8 h. DMA (2 ml) was added, and the mixture was heated at 80° C. for 4 h. The mixture was cooled to rt, diluted with EtOAc (120 ml), washed with H2O (6×80 ml) and brine (1×80 ml), dried (MgSO4) and filtered. The filtrate was concentrated to give 12A (280 mg, 85%).

Provenance & Evidence