Trifluoroacetic acid → [5-(4-Amino-piperidin-1-ylmethyl)-pyrrolo[2,1-f][1,2,4]triazin-4-yl]-[3-chloro-4-(pyridin-4-ylmethoxy)-phenyl]-amine

Participants

Role	Name	HCID	Charge
Reactant	Trifluoroacetic acid	HCID 6422	—
Reactant	5-((4-aminopiperidin-1-yl)methyl)-N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine	HCID 11178756	—
Reactant	(1-{4-[3-Chloro-4-(pyridin-4-ylmethoxy)-phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl}-piperidin-4-yl)-carbamic acid, tert-butyl ester	HCID 21031526	—
Solvent	Methanol	HCID 887	—
Product	[5-(4-Amino-piperidin-1-ylmethyl)-pyrrolo[2,1-f][1,2,4]triazin-4-yl]-[3-chloro-4-(pyridin-4-ylmethoxy)-phenyl]-amine	HCID 22055288	—

Reaction Steps

Compound 21C (31 mg) was prepared from 21B by a route analogous to that used for the preparation of 1G as a white solid. Analytical HPLC retention time=1.480 min. (Chromolith Speed ROD column 4.6×50 mm, 10–90% aqueous methanol over 4 minutes containing 0.2% trifluoroacetic acid, 4 mL/min, monitoring at 254 nm) and a LC/MS M++1=464+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07064203B2
Source dataset	uspto-grants-2006_06
ORD ID	ord-70b15bd8d41c498e81cc60beb5d3fe52
Source note	uspto-grants-2006_06