N,N-Dimethylethylenediamine → N-[2-(dimethylamino)ethyl]-6-nitro-1H-indole-2-carboxamide

Participants

Reaction Steps

500 mg (2.27 mmole) 6-Nitro-1H-indole-2-carboxylic acid methyl ester was dissolved in 4 mL neat N1,N1-dimethyl-ethane-1,2-diamine, was kept at 55° C. overnight and was evaporated. The oily residue was triturated with n-hexane to give 528 mg (84%) yellow solid which was no further purified. MS: 277.13 (calcd for M+H+: 277.13).

Provenance & Evidence